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	Provedor de dados BJID (1) Autor Borges,Larissa Maria Guimarães (1) Ferreira,Michelle Valéria Dias (1) Gomes,Margarete do Socorro Mendonça (1) Rivera,Juan Gonzalo Bardarez (1) Vieira,José Luiz Fernandes (1) Palavra-chave Infectious disease (1) Malaria (1) Mefloquine (1) Parasitology (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2016 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Patient age does not affect mefloquine concentrations in erythrocytes and plasma during the acute phase of falciparum malaria BJID Vieira,José Luiz Fernandes; Borges,Larissa Maria Guimarães; Ferreira,Michelle Valéria Dias; Rivera,Juan Gonzalo Bardarez; Gomes,Margarete do Socorro Mendonça. Abstract Objective To evaluate whether patient age has a significant impact on mefloquine concentrations in the plasma and erythrocytes over the course of treatment for uncomplicated falciparum malaria. Methods A total of 20 children aged between 8 and 11 years and 20 adult males aged between 22 and 41 years with uncomplicated falciparum malaria were enrolled in the study. Mefloquine was administered to patients in both age groups at a dose of 20 mg kg−1. The steady-state drug concentrations were measured by reversed-phase high performance liquid chromatography. Results All patients had an undetectable mefloquine concentration on day 0. In adults, the plasma mefloquine concentrations ranged from 770 to 2930 ng mL−1 and the erythrocyte concentrations... Tipo: Info:eu-repo/semantics/article Palavras-chave: Malaria; Infectious disease; Parasitology; Mefloquine. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500482 Registros recuperados: 1 Primeira ... 1 ... Última

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